Risk of amniocentesis in women screened positive for Down syndrome with second trimester maternal serum markers
Identifieur interne : 000F03 ( France/Analysis ); précédent : 000F02; suivant : 000F04Risk of amniocentesis in women screened positive for Down syndrome with second trimester maternal serum markers
Auteurs : Françoise Muller [France] ; Didier Thibaud [France] ; Françoise Poloce [France] ; Marie-Christine Gelineau [France] ; Marguerite Bernard [France] ; Christine Brochet [France] ; Christine Millet [France] ; Jean-Yves Réal [France] ; Marc Dommergues [France]Source :
- Prenatal Diagnosis [ 0197-3851 ] ; 2002-11.
English descriptors
Abstract
In routine obstetrical practice, prior to offering invasive prenatal diagnosis, it is crucial to weigh the risks attendant on amniocentesis against the individual's risk of aneuploidy. We took advantage of a policy of follow‐up of patients undergoing Down syndrome maternal serum screening to compare the rates of fetal loss before 24 weeks and of early premature delivery at 24–28 weeks between women who underwent amniocentesis and women who did not. A total of 54 902 patients entered the study, of whom 4039 (7.35%) were lost to follow‐up and 387 were excluded because of a severe fetal abnormality. Of the 50 476 remaining patients, 3472 had an amniocentesis whereas 47 004 had not and served as controls. In the amniocentesis group, the fetal loss rate before 24 weeks was 1.12% (95% CI=1.08–1.15) and the 24–28 weeks premature delivery rate was 0.40% (95% CI=0.39–0.41) which was significantly higher than in controls (0.42% with 95% CI 0.41–0.43 and 0.24% with 95% CI 0.23–0.25, respectively). The 0.86% difference in adverse outcome rates between the amniocentesis and control groups may be attributable to amniocentesis and compares favourably with the positive predictive value of maternal serum markers (1.70%) observed in the present study. Copyright © 2002 John Wiley & Sons, Ltd.
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DOI: 10.1002/pd.449
Affiliations:
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Diagn.</title><idno type="ISSN">0197-3851</idno><idno type="eISSN">1097-0223</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2002-11">2002-11</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1036">1036</biblScope><biblScope unit="page" to="1039">1039</biblScope></imprint><idno type="ISSN">0197-3851</idno></series><idno type="istex">DD4D69CC23D62FE61B1E91348CFAE75BBA70F7D6</idno><idno type="DOI">10.1002/pd.449</idno><idno type="ArticleID">PD449</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0197-3851</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>amniocentesis</term><term>fetal loss</term><term>premature birth</term><term>prenatal diagnosis</term><term>trisomy 21</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In routine obstetrical practice, prior to offering invasive prenatal diagnosis, it is crucial to weigh the risks attendant on amniocentesis against the individual's risk of aneuploidy. We took advantage of a policy of follow‐up of patients undergoing Down syndrome maternal serum screening to compare the rates of fetal loss before 24 weeks and of early premature delivery at 24–28 weeks between women who underwent amniocentesis and women who did not. A total of 54 902 patients entered the study, of whom 4039 (7.35%) were lost to follow‐up and 387 were excluded because of a severe fetal abnormality. Of the 50 476 remaining patients, 3472 had an amniocentesis whereas 47 004 had not and served as controls. In the amniocentesis group, the fetal loss rate before 24 weeks was 1.12% (95% CI=1.08–1.15) and the 24–28 weeks premature delivery rate was 0.40% (95% CI=0.39–0.41) which was significantly higher than in controls (0.42% with 95% CI 0.41–0.43 and 0.24% with 95% CI 0.23–0.25, respectively). The 0.86% difference in adverse outcome rates between the amniocentesis and control groups may be attributable to amniocentesis and compares favourably with the positive predictive value of maternal serum markers (1.70%) observed in the present study. Copyright © 2002 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Béziers</li><li>Le Havre</li><li>Lyon</li><li>Paris</li><li>Poitiers</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Muller, Francoise" sort="Muller, Francoise" uniqKey="Muller F" first="Françoise" last="Muller">Françoise Muller</name></noRegion><name sortKey="Bernard, Marguerite" sort="Bernard, Marguerite" uniqKey="Bernard M" first="Marguerite" last="Bernard">Marguerite Bernard</name><name sortKey="Brochet, Christine" sort="Brochet, Christine" uniqKey="Brochet C" first="Christine" last="Brochet">Christine Brochet</name><name sortKey="Dommergues, Marc" sort="Dommergues, Marc" uniqKey="Dommergues M" first="Marc" last="Dommergues">Marc Dommergues</name><name sortKey="Gelineau, Marie Hristine" sort="Gelineau, Marie Hristine" uniqKey="Gelineau M" first="Marie-Christine" last="Gelineau">Marie-Christine Gelineau</name><name sortKey="Millet, Christine" sort="Millet, Christine" uniqKey="Millet C" first="Christine" last="Millet">Christine Millet</name><name sortKey="Poloce, Francoise" sort="Poloce, Francoise" uniqKey="Poloce F" first="Françoise" last="Poloce">Françoise Poloce</name><name sortKey="Real, Jean Ves" sort="Real, Jean Ves" uniqKey="Real J" first="Jean-Yves" last="Réal">Jean-Yves Réal</name><name sortKey="Thibaud, Didier" sort="Thibaud, Didier" uniqKey="Thibaud D" first="Didier" last="Thibaud">Didier Thibaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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